The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants, and urine.
A brain-derived neurotrophic factor (BDNF) gene mapped onto human chromosome 11p14.1. BDNF belongs to the neurotrophin growth factor family. There are many companies available that provide the human BDNF ELISA kit online.
The gene encodes the precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Both proBDNF and mBDNF play an important role in the transmission of cellular signals.
For research use only, these are used. Not used in diagnostic procedures. A Human BDNF ELISA kit was used to determine the effect of mesenchymal bone marrow stem cell transplantation (MSC) on BDNF protein expression in Striatus of Tourette syndrome (TS) in mice. It is also used to determine plasma BDNF levels in patients with GD1 (Gaucher type 1) and to control populations.
Human BDNF ELISA kit used:
• Measurement of brain-derived neurotrophic factor protein (BDNF) expression
• Determination of BDNF levels in culture media and extracts from organotypic cultures from brain slices (OBSC)
• To determine the level of BDNF in plasma
Brain-derived neurotrophic factor (BDNF) is involved in hippocampal function and episodic verbal memory in humans. Therefore, variations in BDNF gene expression alter this neurological function.
BDNF also plays an important role in vascular function and is involved in angiogenesis via the specific receptor tropomyosin-linked kinase B (TrkB). It is involved in the pathogenesis of Alzheimer's disease. ProBDNF interacts with the neurotrophin p75 receptor, causing long-term depression in the hippocampus.